Resource Center - Lyoinnovation

Application of Tunable Diode Laser Absorption Spectroscopy (TDLAS) to Monitoring Pharmaceutical Lyophilization

This technical brief provides an overview of Tunable Diode Laser Absorption Spectroscopy (TDLAS) and its application for monitoring freeze drying processes.

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Basic Principles of Freeze Drying

Freeze-drying is the removal of ice or other frozen solvents from a material through the process of sublimation and the removal of bound water molecules through the process of desorption.

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Equipment Capability Measurement of Laboratory Freeze-Dryers: a Comparison of Two Methods

The objective of this investigation was to evaluate two methods for measuring the maximum sublimation rate that a freeze-dryer will support—the minimum controllable pressure method and the choke point method.

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Failure of Glass Tubing Vials during Lyophilization

Lyophilization consists of changing a liquid pharmaceutical product into a dry solid “cake” by means of a freeze/dry process.

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PCR Diagnostic Kits & Freeze-Drying Considerations

Polymerase chain reaction (PCR) is a method widely used in molecular biology to make many copies of a specific DNA segment.

pdf | 430.79k

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Rational Design of Stable Lyophilized Protein Formulations

Why use lyophilization to prepare stable protein drug products?

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Impact of the Freeze-Drying Process and Lyoprotectants on Nanoparticle Stability

Nanoparticles are extremely diverse, ranging from solid lipid structures to liposomes and even designs that incorporate gold/silica particles.

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Freeze Drying of Vaccines – Challenges and Concepts in Formulation and Process Development

There are still millions of people who die from these diseases due to weak thermostability demanding cold chains, long-term stability issues and distribution challenges.

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