Quantifying Lyo Cake
Robustness
The MicroPress is an instrument which can quantitively determine the strength and physical characteristics of freeze-dried cakes in-situ. With set parameters and analysis methods the MicroPress will be able to analyse your freeze-dried cake structure. This allows for fast and effective batch screening to be applied to your products, especially when time and personnel costs are at such a premium; with a standard method the analysis can be completed in less than one minute per freeze dried cake.
MicroPress is able to provide pivotal data as to whether or not the products produced will be able to survive the potentially destructive process of shipping from manufacturing site to clinical sites, or even to your local pharmacy. While the MicroPress analysis will leave a small indentation on the cake surface, the cakes can still be used for other types of analysis such as Karl-Fischer and DSC to provide yet more information. A small batch will be needed to provide quantitative data on how likely, or not, the freeze-dried product will survive transport.
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Frozen State Analysis
Add a new dimension to the data of this critical stage: the Lyotherm3 combines electrical and thermal techniques, enabling you to do two analyses at the same time:
Impedance Analysis (ZSinφ): is a fixed frequency dielectric analysis providing an indication of molecular mobility, including events not picked up by thermal methods like DTA or DSC.
Differential Thermal Analysis (DTA): measures the difference in temperature between a sample and a reference, highlighting exothermic and endothermic events e.g. crystallisation, eutectic melting and glass transitions.
Optimised for frozen state analysis: identifies viscosity changes and critical parameters of samples such as Tg', crystal transitions, Teu and softenings within the frozen structure.
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Moisture Content
Karl Fischer moisture determination method has been recognized as the most accurate method by many international standards, such as ISO, ASTM, DIN, BS, JIS, etc. This method is suitable for the determination of moisture content of various substances.
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